Antisecretory therapy for bleeding peptic ulcer.
نویسندگان
چکیده
Specific interventions included in the review Proton pump inhibitors (PPIs) (omeprazole (either 80 mg bolus, then 40 mg IV every 8 hours for 24 hours then 40 mg orally every 12 hours, or 80 mg bolus then 40 mg IV every 12 hours or every 8 hours, or 40 mg bolus then 6.7 mg/hour IV, or 40 mg orally every 12 hours)) for the intervention group and placebo or ranitidine (50 mg IV every 4 hours or 6 hours) or cimetidine (50 mg/hour IV) in the control groups.
منابع مشابه
H. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer.
BACKGROUND Peptic ulcer is the main cause for upper gastrointestinal haemorrhage, and Helicobacter pylori infection is the main etiologic factor for peptic ulcer disease. Maintenance antisecretory therapy has been the standard long-term treatment for patients with bleeding ulcers to prevent recurrent bleeding. On the other hand, the precise efficacy of H. pylori eradication for the prevention o...
متن کاملReview article: uninvestigated dyspepsia and non-ulcer dyspepsia-the use of endoscopy and the roles of Helicobacter pylori eradication and antisecretory therapy.
Due to its prevalence, impact on quality-of-life and the associated significant health resource utilization, dyspepsia is a major healthcare concern. The available management strategies for uninvestigated dyspepsia include prompt endoscopy, the 'test-and-treat' strategy for Helicobacter pylori, and empiric antisecretory therapy. There is consensus that endoscopy should be reserved for patients ...
متن کاملThe need for Helicobacter pylori eradication therapy in patients with peptic ulcer bleeding.
Peptic ulcer bleeding is an important complication of peptic ulceration. The condition carries significant morbidity and mortality despite advances in both endoscopic intervention techniques and pharmacological treatment. About one third of patients have a recurrence of bleeding within a few years of discharge. Before Helicobacter pylori was discovered, most of these patients were given mainten...
متن کاملEradication of Helicobacter pylori for the prevention of peptic ulcer rebleeding.
AIM To evaluate the effect of Helicobacter pylori eradication on ulcer bleeding recurrence in a prospective, long-term study including more than 400 patients. METHODS Patients with peptic ulcer bleeding were prospectively included. H. pylori infection was confirmed by rapid urease test, histology or (13)C-urea breath test. Several eradication regimens were used. Ranitidine 150 mg was administ...
متن کاملSystematic review and meta-analysis: Helicobacter pylori eradication therapy after simple closure of perforated duodenal ulcer.
BACKGROUND The most common complications of peptic ulcer are bleeding and perforation. In many regions, definitive acid reduction surgery has given way to simple closure and Helicobacter pylori eradication. AIM To perform a systematic review and meta-analysis to ask whether this change in practice is in fact justified. MATERIALS AND METHODS A search on the Cochrane Controlled Trials Registe...
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ورودعنوان ژورنال:
- JAMA
دوره 280 10 شماره
صفحات -
تاریخ انتشار 1998